relation: http://miis.maths.ox.ac.uk/miis/578/
title: Interpreting pharmaceutical screening test results
creator: D., Allwright
subject: Medical and pharmaceutical
description: In the pharmaceutical industry, compounds are tested for activity against  a disease target. In a High Throughput Assay (HTA), each compound is  tested at a single concentration. In an IC50 test, a compound is tested  at a range of concentrations. Sometimes there are discrepancies between  the results of these tests and the Study Group was asked to model this.  Rather than assume normally distributed errors in the percentage effect,  the Study Group proposed a model in which there are also probabilities  p and q of a test erroneously indicating very low or high activity. The  parameters p and q can be estimated from the data, and then can be  used in the design of testing procedures.
date: 2011
type: Study Group Report
type: NonPeerReviewed
format: application/pdf
language: en
identifier: http://miis.maths.ox.ac.uk/miis/578/1/6.pdf
identifier:   D., Allwright  (2011) Interpreting pharmaceutical screening test results.  [Study Group Report]